Did You Know? R-PLUS Curcumin Features BCM-95

What is BCM-95 and who cares? you might ask...

""Six-month, Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients with Alzheimer Disease," Baum L, Wai Kei Lam C, et al, Journal of Clinical Psychopharmacology, 2008; 28: 110-13. (Address: Larry Baum, Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong. E-mail: lwbaum@cuhk.edu.hk ).

Summary: In a 6-month, randomized, double-blind, placebo-controlled pilot clinical trial involving 22 patients with Alzheimer's disease, supplementation with a particular curcumin supplement (BCM-95 capsules) was found to have significantly greater bioavailability, as compared to conventional curcumin powder, suggesting it may provide better clinical benefits. Subjects (aged 50 years of age or older) with progressive decline in memory or cognitive function, diagnosed with probable or possible Alzheimer's disease were given: 1.0 g/d curcumin, 4.0 g/d curcumin, or placebo, taken after a meal (capsules) or mixed with food (powder), for a period of 6 months. Supplementation with curcumin was found to increase levels of serum Abeta, possibly reflecting the ability of curcumin to disaggregate Abeta deposits in the brain. Significant increases in vitamin E were found as well, with greater increases found among subjects who took the BCM-95 capsulses. In addition, BMC-95 was absorbed 7.8 times more than conventional curcumin; this bioavailability may confer greater clinical benefits. The authors recommend that BCM-95 be used in future clinical trials. A larger trial of a longer duration is warranted."

Geronova Research R-PLUS Curcumin uses the highly bioavailable BCM-95 material. Oh and don't forget, it is on sale now.

Quality matters!
Pete

The Buzz on Bing

Go check out Bing.com - Microsoft's alternative to Google search.

Yes Microsoft is the company we love and hate. And yes a lot of their products may not live up to expectation. BUT. Bing is an internet search engine that is fast, looks good and returns relevant results.

I am impressed and have been using it the past week with satisfaction. See what you think?

My Emails and Phone Calls...

Do you sell powders???
Why is the price different from the last time I ordered???
Will you send me free samples????
Can you give me free shipping???
I am broke (old/in school/sick/bankrupt) and need to buy some stuff, can you help me out??
Here are my health problems, what would you prescribe???
Will you take my $9.95 phone order? And oh yeah, I need to ask you questions for two hours...

Oh.. and- "where is my (international) package sent via First Class Mail?" (NO tracking and dirt cheap cost)

and... "why did you bill my credit card 2/3/6/gazillion times???""Don't f' with me! I will report you!!" (some customers keep trying to submit orders with incorrect cc info. Over, and over. I finally built a credit card tutorial page just to explain this)

I think I will stop answering the phone and reading emails :-)

Seriously, all in all I have a fantastic customer base. But man oh man the same old crap (from a precious few) sure gets tiresome (and provokes an occasional rant like this).

Had to post this. Enjoy.

Curcumin and Chronic Fatigue Syndrome (CFS)

Interesting study (and particularly timely with our Geronova Research R-PLUS with Curcumin on sale):

"Chronic fatigue syndrome affects millions of people in the United States, making it virtually impossible for many of them to hold a full-time or even part-time job, go to school, enjoy their families, or participate in routine or leisure activities. Estimates of the actual number of people who have the disease vary widely, from 500,000 to more than 4 million.

Study of curcumin and chronic fatigue
Oxidative stress is a significant factor in chronic fatigue syndrome, and so ways to reduce it theoretically should also improve symptoms of this complex condition. A study published in the January 2009 issue of Immunobiology reports on mice who were challenged with a stress test for 10 minutes daily for 19 days. Half of the mice were given curcumin and the other half acted as controls.

The control mice showed signs of significant fatigue and had hyperalgesia (increased sensitivity to pain), another common symptom of the syndrome. The mice who were given curcumin showed a significant reduction in fatigue, oxidative stress, and hyperalgesia. The investigators suggest that curcumin may be a valuble option in the treatment of chronic fatigue syndrome.

Curcumin in patients with chronic fatigue syndrome
Along with an increase in oxidative stress, research shows that chronic fatigue syndrome is accompanied by activation of the inflammatory response system, and that a natural agent called nuclear factor kappa beta (NFkappabeta) is the main intracellular mechanism that regulates inflammatory and oxidative stress mediators.

In a Belgian study, researchers studied the possible impact of inhibiting the production of NFkappabeta in patients who had chronic fatigue syndrome. They found that there were significant correlations between the production of NFkappabeta and symptoms typically associated with the syndrome, including muscular tension, fatigue, irritability, depression, a subjective feeling of infection, and aches and pain.

They also discovered that the increase in oxidative stress and inflammation reported in previous studies of chronic fatigue syndrome may be caused by increased production of NFkappabeta. Given these results, the study’s authors suggest that people with chronic fatigue syndrome should be treated with antioxidants that are known to inhibit the production of NFkappabeta, including curcumin, quercetin, lipoic acid, and omega-3 fatty acids.

Curcumin for chronic fatigue syndrome
Curcumin is one of several curcuminoids, the natural pigments that give the spice turmeric its yellow color. It has both antioxidant and anti-inflammatory properties, and as such it is also used to treat arthritis, inflammatory bowel disease, and to help maintain a healthy cardiovascular system."

Relentless Improvement Resveratrol Sale

The existing supply of RI brand 300mg, 98% documented purity Resveratrol is nearly sold out. Order NOW to stock up on top-quality resveratrol extract at short-expiry (July 2009) fire sale blow out pricing.

Public interest in resveratrol has especially skyrocketed ever since the 60 Minutes special on David Sinclair and Sirtris pharmaceuticals. Who doesn't want a purported fountain of youth in pill form?

We have to be skeptical until more research is completed, but the early indications are very intriguing. And perhaps, depending upon your viewpoint, worth beginning a daily regimen of high purity, high-quality resveratrol.

Get it while the 'gettin is good!

Cheers,
Pete Hitesman
Relentless Improvement LLC

Green Tea Extract (EgCG) Shows Promise In Leukemia (CLL)Trials

Wow. This is some good news regarding EgCG Green Tea Extract:

"ScienceDaily (May 27, 2009) — Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea."

"In the first clinical trial, 33 patients received variations of eight different oral doses of Polyphenon E, a proprietary compound whose primary active ingredient is EGCG. Doses ranged from 400 milligrams (mg) to 2,000 mg administered twice a day. Researchers determined that they had not reached a maximum tolerated dose, even at 2,000 mg twice per day."

I just updated our EgCG high-potency, high-purity green tea extract to offer 393mg EgCG per dose. Capsules are smaller and easier to swallow. Our documented purity product assures no worries from mold/microbial/heavy metal contamination that could be risky with cheap low-quality, low-potency brands.

Pete

Idebenone

Folks have discovered what a good value we offer with our 150mg Idebenone capsules.

I see a lot of Google advertisers are offering low milligram capsules at very high prices. Relentless has several levels of compelling discounts when our customers order in quantity.

Idebenone is a very interesting analog of CoQ10 and indeed thought by many to be superior to CoQ10. People seeking cognition support often pair Idebenone with other cognitive enhancement materials such as Piracetam and Oxiracetam.

RevGenetics Resveratrol Now In Stock

Woo-Hoo, RevGenetics has been doing some very cool things with resveratrol formulations over the past few years. Relentless Improvement now stocks their x1000, 1000mg resveratrol 99% product and new 250mg micronized resveratrol LiCaps.

I have always admired what the owner, Anthony Loera, has done to build RevGenetics as a business and the integrity which he brings to the supplement business. Like Relentless Improvement brand products, his products also carry independent Certificates of Analysis to fully document their purity and claimed content.

Now you have several new choices when shopping for a true pharmaceutical grade resveratrol extract.

New: Neurvana MoodBrightener and Neurvana Tranquil

Neurvana is a new company with some very innovative formulations. Some of the very best I have ever seen.

New, and in stock.

NEURVANA™ MoodBrightener is a synergistic combination of neurotransmitter precursors and activators that synthesize biogenic catecholamines during the day. They can quickly boost depressive moods, ease-away tension, block stressful feelings, increase attention, stabilize moods, and make you feel good.

NEURVANA MoodBrightener:

NEURVANA™ Tranquil is a combination of neural inhibitors and indoleamine transmitter activators of the Nighttime Sleep & Repair Cycle for relaxation, calmness, stress-relief and restful sleep for occasional sleeplesness.

NEURVANA Tranquil:

As always, there is a lot more info on the respective product pages. An exclusive bonus for you for being a loyal blog reader- links to Dr. Richard Kaufman's fantastic technical treatise on his theory of "Chronobiology". Linked here Part 1 and Part .

This is amazing reading and I urge you to click the links above.

Full line of Neurvana products at the following link
NEURVANA

As always, thank you for your trust and support!
Pete Hitesman-Owner

New: Mito-Charger with Benagene from Advanced Orthomolecular Research

This MitoCharger Information link offers a sneak-peek at the forthcoming full write-up.

Mito Charger was formulated to attack a central theory of aging at its source.

Enhances mitochondrial activity on six different levels.

Supports the health of mitochondria.

"The ingredient BenaGene ® contains a key intermediate in the Kreb's Cycle. Studies demonstrate that benaGene mimics a caloric restriction diet, which has been shown to increase the expression of beneficial genes associated with increased life span, health span, weight management and blood glucose reduction."

Other ingredients include Benfotiamine, Acetyl-L-Carnitine, CoQ10 and D-Uridine.

In stock and shipping now.